Efficacy of intravenous paracetamol compared to placebo in the prevention of patent ductus arteriosus in very preterm newborns
dc.contributor
dc.contributor.author
dc.contributor.other
dc.date.accessioned
2018-06-26T10:17:01Z
dc.date.available
2018-06-26T10:17:01Z
dc.date.issued
2017-11
dc.identifier.uri
dc.description.abstract
PDA.
OBJECTIVE : The purpose of the present study is to determine the efficacy of
paracetamol in the prevention of PDA in comparison to placebo in very preterm
newborns. Safety of paracetamol will also be assessed.
DESIGN AND SETTING : A triple-blinded randomized trial will be performed
among the Neonatal Intensive Care Units (NICUs) of Hospital universitari Dr.
Josep Trueta in Girona and Hospital universitari Vall d’Hebron in Barcelona.
PARTICIPANTS, INTERVENTION AND METHOD: A total of 336 prematures under
32 weeks of gestation will be randomized into one of the two treatment groups.
One group will be receiving paracetamol (loading dose of 20 mg/kg followed by
a maintenance dose of 7.5 mg/kg/6h) while the other group will receive
placebo. Follow-up echocardiographies will be held on day three and seven
after beginning of treatment, as well as on month one and three, to asses the
presence or not of PDA, which will be the main outcome. Physical exploration,
blood analysis and transfontanellar echographies will be held regularly to
evaluate drug adverse effects and comorbidities, to assess secondary outcomes
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.relation.ispartofseries
Medicina (TFG)
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.subject
dc.title
Efficacy of intravenous paracetamol compared to placebo in the prevention of patent ductus arteriosus in very preterm newborns
dc.type
info:eu-repo/semantics/bachelorThesis
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.audience.educationlevel
Estudis de grau
dc.coverage.geolocation
east=2.819998700000042; north=41.997504; name=Hospital Universitari de Girona Doctor Josep Trueta
east=2.1418727000000217; north=41.4278967; name=Hospital Universitari Vall d'Hebrón
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