Determining the Pathogenicity of Genetic Variants Associated with Cardiac Channelopathies
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Advancements in genetic screening have generated massive amounts of data on genetic variation; however, a
lack of clear pathogenic stratification has left most variants classified as being of unknown significance. This
is a critical limitation for translating genetic data into clinical practice. Genetic screening is currently
recommended in the guidelines for diagnosis and treatment of cardiac channelopathies, which are major
contributors to sudden cardiac death in young people. We propose to characterize the pathogenicity of
genetic variants associated with cardiac channelopathies using a stratified scoring system. The development
of this system was considered by using all of the tools currently available to define pathogenicity. The use of
this scoring system could help clinicians to understand the limitations of genetic associations with a disease,
and help them better define the role that genetics can have in their clinical routine