The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach
dc.contributor.author
dc.date.accessioned
2018-03-20T09:37:48Z
dc.date.available
2018-03-20T09:37:48Z
dc.date.issued
2013
dc.identifier.uri
dc.description.abstract
Cerebral hypoperfusion induced by bilateral common carotid artery occlusion (BCCAo) in rodents has been proposed
as an experimental model of white matter damage and vascular dementia. However, the histopathological and
behavioral alterations reported in this model are variable and a full characterization of the dynamic alterations is not
available. Here we implemented a longitudinal multimodal magnetic resonance imaging (MRI) design, including timeof-
flight angiography, high resolution T1-weighted images, T2 relaxometry mapping, diffusion tensor imaging, and
cerebral blood flow measurements up to 12 weeks after BCCAo or sham-operation in Wistar rats. Changes in MRI
were related to behavioral performance in executive function tasks and histopathological alterations in the same
animals. MRI frequently (70%) showed various degrees of acute ischemic lesions, ranging from very small to large
subcortical infarctions. Independently, delayed MRI changes were also apparent. The patterns of MRI alterations
were related to either ischemic necrosis or gliosis. Progressive microstructural changes revealed by diffusion tensor
imaging in white matter were confirmed by observation of myelinated fiber degeneration, including severe optic tract
degeneration. The latter interfered with the visually cued learning paradigms used to test executive functions.
Independently of brain damage, BCCAo induced progressive arteriogenesis in the vertebrobasilar tree, a process
that was associated with blood flow recovery after 12 weeks. The structural alterations found in the basilar artery
were compatible with compensatory adaptive changes driven by shear stress. In summary, BCCAo in rats induces
specific signatures in multimodal MRI that are compatible with various types of histological lesion and with marked
adaptive arteriogenesis
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science (PLoS)
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1371/journal.pone.0074631
dc.relation.ispartof
PLoS One, 2013, vol. 8, núm. 9, p. e74631
dc.relation.ispartofseries
Articles publicats (D-CM)
dc.rights
Attribution 4.0 Spain
dc.rights.uri
dc.subject
dc.title
The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
022023
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1932-6203