Synthesis of new Cobalt complexes with carborane-type ligands for its potential application in BNCT (Boron Neutron Capture Therapy)

Abstract

In this dissertation work we have developed and optimized a synthetic route to obtain different cobalt complexes with carborane-type ligands, with the idea to obtaining high boron compounds that present a good solubility in water for its application in the medicine field, since the main use of the boron clusters is in the cancer treatment by electron capture therapy or BNCT (Boron Neutron Capture Therapy). The first section of the dissertation is focused on the synthesis of this cobalt complexes. First of all, sodium salts (sodium benzoate and 1-COONa-p-C2B10H11) have been synthesized to be used as nucleophiles in the synthesis of some of the compounds. The second section of the dissertation is focused on the characterization of all new complexes that contain carboxylic and carboranylcarboxylic ligands. Complexes have been synthesized and characterized in the solid state by analytical techniques and in dissolution using spectroscopic techniques (NMR, IR, UV-visible and ESI-MS). Finally, redox properties of two of the synthesized compounds have been studied by cyclic voltammetry