Delineating the Factors and Cellular Mechanisms Involved in the Survival of Cerebellar Granule Neurons
dc.contributor.author
dc.date.accessioned
2018-03-13T07:38:14Z
dc.date.available
2018-03-13T07:38:14Z
dc.date.issued
2015-06-26
dc.identifier.issn
1473-4222
dc.identifier.uri
dc.description.abstract
Cerebellar granule neurons (CGNs) constitute the most abundant neuronal population in the mammalian brain. Their postnatal generation and the feasibility to induce their apoptotic death in vitro make them an excellent model to study the effect of several neurotransmitters and neurotrophins. Here, we first review which factors are involved in the generation and proliferation of CGNs in the external granule layer (EGL) and in the regulation of their differentiation and migration to internal granule layer (IGL). Special attention was given to the role of several neurotrophins and the NMDA subtype of glutamate receptor. Then, using the paradigm of potassium deprivation in cultured CGNs, we address several extracellular factors that promote the survival of CGNs, with particular emphasis on the cellular mechanisms. The role of specific protein kinases leading to the regulation of transcription factors and recent data involving the small G protein family is also discussed. Finally, the participation of some members of Bcl-2 family and the inhibition of mitochondria-related apoptotic pathway is also considered. Altogether, these studies evidence that CGNs are a key model to understand the development and the survival of neuronal populations
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Springer Verlag
dc.relation.isformatof
Versió postprint del document publicat a: https://doi.org/10.1007/s12311-015-0646-z
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© Cerebellum, 2015, vol. 14, núm. 3, p. 354-359
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Articles publicats (D-CM)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Delineating the Factors and Cellular Mechanisms Involved in the Survival of Cerebellar Granule Neurons
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.identifier.idgrec
022718
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1473-4230