Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance
dc.contributor.author
dc.date.accessioned
2018-02-27T10:58:17Z
dc.date.available
2018-02-27T10:58:17Z
dc.date.issued
2018
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dc.description.abstract
Ovarian cancer has the highest mortality rate among all the gynecological cancers. This is mostly due to the resistance of ovarian cancer to current chemotherapy regimens. Therefore, it is of crucial importance to identify the molecular mechanisms associated with chemoresistance.
Methods: NCI/ADR-RES is a multidrug-resistant cell line that is a model for the study of drug resistance in ovarian cancer. We carried out a microarray-derived transcriptional profiling analysis of NCI/ADR-RES to identify differentially expressed genes relative to its parental OVCAR-8.
Results: Gene-expression profiling has allowed the identification of genes and pathways that may be important for the development of drug resistance in ovarian cancer. The NCI/ADR-RES cell line has differential expression of genes involved in drug extrusion, inactivation, and efficacy, as well as genes involved in the architectural and functional reorganization of the extracellular matrix. These genes are controlled through different signaling pathways, including MAPK–Akt, Wnt, and Notch.
Conclusion: Our findings highlight the importance of using orthogonal therapies that target completely independent pathways to overcome mechanisms of resistance to both classical chemotherapeutic agents and molecularly targeted drugs
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Dove Medical Press
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Reproducció digital del document publicat a: https://doi.org/10.2147/OTT.S154378
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OncoTargets and Therapy, 2018, vol. 11, p. 221-237
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Articles publicats (D-B)
dc.rights
Attribution-NonCommercial 3.0 Spain
dc.rights.uri
dc.title
Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
027558
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1178-6930