Prevalence of lower extremity peripheral arterial disease in individuals with chronic immune mediated inflammatory disorders
dc.contributor.author
dc.date.accessioned
2018-02-20T16:13:07Z
dc.date.available
2018-02-20T16:13:07Z
dc.date.issued
2015-09
dc.identifier.issn
0021-9150
dc.identifier.uri
dc.description.abstract
To compare the prevalence of lower extremity peripheral artery disease (PAD) and to assess whether age-associated progression in ankle-brachial index (ABI) differs between individuals with chronic immune-mediated inflammatory diseases (CIID) and the general population.
Methods
Pooled analysis with data from individuals aged 50 years and older with ABI measurements, obtained from population-based cross-sectional studies conducted in Catalonia (Spain). Information on three CIID diagnoses (i.e., inflammatory bowel disease, systemic connective tissue disorders, and inflammatory polyarthropathies and spondylopathies, considered as one entity for purposes of analysis) was obtained from electronic medical records. To ascertain the statistical association between PAD and CIID, logistic regression models were fitted and adjusted for age, sex, and cardiovascular risk factors. We tested the interaction between age and CIID diagnosis for ABI values.
Results
We included 8799 individuals, 312 (3.6%) with CIID. The age-standardized prevalence of PAD was higher in the CIID group (12% vs. 6% in general population, p = 0.001), and the model adjusted for age, sex, and cardiovascular risk factors also showed higher risk in individuals with CIID [Odds Ratio (95% confidence interval) = 1.65 (1.15–2.38); p = 0.007]. The inflammatory polyarthropathies/spondylopathies diagnosis was significantly associated with PAD in the fully adjusted model [1.80 (1.18–2.75); p = 0.006]. The atherosclerotic process was accelerated in individuals with CIID, compared to the general population (p for interaction < 0.001).
Conclusion
In individuals with CIID, age-standardized prevalence of PAD was significantly higher than in the general population and the atherosclerotic process was accelerated. However, only inflammatory polyarthropathies/spondylopathies was associated with significant risk of PAD
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1016/j.atherosclerosis.2015.06.054
dc.relation.ispartof
Atherosclerosis, 2015, vol. 242, p. 1-7
dc.relation.ispartofseries
Articles publicats (D-CM)
dc.rights
Attribution-NonCommercial-NoDerivs 4.0 Spain
dc.rights.uri
dc.title
Prevalence of lower extremity peripheral arterial disease in individuals with chronic immune mediated inflammatory disorders
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
023745
dc.type.peerreviewed
peer-reviewed