A family of manganese complexes containing heterocyclic-based ligands with cytotoxic properties
dc.contributor.author
dc.date.accessioned
2018-02-20T12:37:06Z
dc.date.available
2018-02-20T12:37:06Z
dc.date.issued
2018-05-01
dc.identifier.issn
0162-0134
dc.identifier.uri
dc.description.abstract
We describe the synthesis of three new manganese (II) complexes containing the bidentate ligands 2-(1-methyl-3-pyrazolyl)pyridine (pypz-Me) and ethyl 2-(3-(pyridine-2-yl)-1H–pyrazol-1-yl)acetate (pypz-CH2COOEt), with formula [MnX2(pypz-Me)2] (X = Cl−1, CF3SO3−2) and [Mn(CF3SO3)2(pypz-CH2COOEt)2] 3. Complexes 1–3 have been characterized through analytical, spectroscopic and electrochemical techniques, as well as by monocrystal X-ray diffraction analysis. The complexes show a six-coordinated Mn(II) ion though different stereoisomers have been isolated for the three compounds. Complexes 1–3, together with the previously described compounds [MnCl2(pypz-H)2] 4, [Mn(CF3SO3)2(pypz-H)2] 5, [Mn(NO3)2(pypz-H)2] 6, [MnCl2(H2O)2(pypz-H)2] 7 (pypz-H = 2-(3-pyrazolyl)pyridine) and ([Mn(CF3SO3)2((−)-L)2] 8, ((−)-L = (−)-pinene[5,6]bipyridine), were tested in vitro for cytotoxic activity against NCI-H460 and OVCAR-8 cancer cell lines. The geometry of a specific compound does not seem to influence its activity in a significant extent. However, among the tested compounds those that display hydrophobic substituents on the pyrazole ring and triflate ions as labile ligands show the best antiproliferative properties. Specifically, compound 8 containing the pinene-bipyridine ligand presents an antiproliferative activity similar to that of cisplatin and higher than that of carboplatin, and displays selectivity for tumour cells. Its antiproliferative effect is due to the generation of ROS species that allow the compound to interact with DNA
dc.description.sponsorship
This research has been financed by Ministerio de Economia y Competitividad (MINECO) Spain, through projects CTQ2015-66143-P and BIO2013-43517, by Universitat de Girona through projects MPCUdG2016-18 and MPCUdG2016/048 and by DGU, Generalitat de Catalunya through projects SGR2014-70 and SGR2014-149
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation
info:eu-repo/grantAgreement/MINECO//CTQ2015-66143-P/ES/COMPLEJOS FUNCIONALES PARA PROCESOS CATALITICOS SOSTENIBLES Y RESPETUOSOS CON EL MEDIO AMBIENTE/
info:eu-repo/grantAgreement/MINECO//BIO2013-43517-R/ES/RIBONUCLEASAS E INTEINAS COMO HERRAMIENTAS MOLECULARES PARA EL DESARROLLO DE FARMACOS ANTITUMORALES Y ESTUDIO DE PROTEINOPATIAS/
dc.relation.isformatof
Versió postprint del document publicat a: https://doi.org/10.1016/j.jinorgbio.2018.01.021
dc.relation.ispartof
© Journal of Inorganic Biochemistry, 2018, vol. 182, p.124-132
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Articles publicats (D-Q)
dc.rights
Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
dc.rights.uri
dc.title
A family of manganese complexes containing heterocyclic-based ligands with cytotoxic properties
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.identifier.idgrec
027758
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
dc.relation.ProjectAcronym
dc.identifier.eissn
1873-3344