Sample preservation for the analysis of antibiotics in water
dc.contributor.author
dc.date.accessioned
2017-09-04T08:01:56Z
dc.date.available
2017-09-04T08:01:56Z
dc.date.issued
2014-11-21
dc.identifier.issn
0021-9673
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dc.description.abstract
This paper describes a stability study performed for 56 antibiotics belonging to 9 different groups - macrolides, tetracyclines, fluoroquinolones, quinolones, penicillins, cephalosporines, lincosamides, sulfonamides and nitroimidazole antibiotics - in purified water samples fortified with the selected compounds at 10. ng/ml. For this purpose, three different sample preservation modes were tested with the aim of avoiding biotic and abiotic degradation: (i) storage at -20. °C, (ii) storage at -20. °C with 0.1% of EDTA and (iii) pre-concentration in a solid phase extraction cartridge (SPE), which was afterwards stored at -20. °C. Concentrations of antibiotics in the samples preserved using the different protocols were monitored after 0, 1, 2 and 12 weeks. The results showed that, for the accurate determination of all compounds they should be analyzed right after sampling. However, if this is not possible, most of the antibiotics can be analyzed within the 1st week after sampling and preservation at -20. °C (with or without EDTA) or in a SPE cartridges at -20. °C. Nonetheless, some antibiotics found extensively in the environment, such as sulfamethoxazole, ciprofloxacin, ofloxacin, erythromycin, azithromycin and clarithromycin exhibited low stability after 1 week preservation and, therefore, they should be analyzed within this time
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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Versió postprint del document publicat a: https://doi.org/10.1016/j.chroma.2014.09.089
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© Journal of Chromatography A, 2014, vol. 1369, p. 43-51
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Articles publicats (ICRA)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Sample preservation for the analysis of antibiotics in water
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.embargo.terms
Cap
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi