Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross‑sectional trial
dc.contributor.author
dc.date.accessioned
2017-05-09T15:26:24Z
dc.date.available
2017-05-09T15:26:24Z
dc.date.issued
2016-10-24
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dc.description.abstract
The cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) can reflect both central and peripheral arterial stiffness. Metabolic syndrome (MetS) and its components may increase arterial stiffness and the risk of cardiovascular diseases. However, the correlation of MetS and its components with arterial stiffness is still not clear. The primary aim of this study is thus the relationship using baPWV and CAVI in Caucasian adults with intermediate cardiovascular risk. The secondary aim is to analyze sex differences.
Methods
This study analyzed 2351 subjects aged 35–74 years (mean, 61.4 ± 7.7 years) comprising 61.7 % males and enrolled in the improving interMediAte Risk management (MARK) study. CAVI was measured using a VaSera VS-1500 ® device, and baPWV was calculated using a validated equation. MetS was defined based on the Joint Scientific Statement National Cholesterol Education Program III. Waist circumference, blood pressure, fasting plasma glucose, and lipid profile were measured.
Results
MetS was found in 51.9 % of the subjects. All MetS components except reduced HDL-cholesterol (p = 0.578) were associated with CAVI. High density lipoprotein cholesterol (p = 0.075) and waist circumference (p = 0.315) were associated with baPWV. The different MetS components that assess dyslipidemia using the stiffness measures show different associations according to patient sex. The high blood pressure component had a greater odds ratio (OR) for both baPWV ≥ 17.5 m/sec (OR = 6.90, 95 % CI 3.52–13.519) and CAVI ≥ 9 (OR = 2.20, 95 % CI 1.63–1.90).
Conclusions
MetS and all its components (except HDL-cholesterol with baPWV and CAVI and WC with baPWV) were associated with baPWV and CAVI. However, there were sex differences in the association of MetS and its components with baPWV and CAVI. Data from this study suggest a greater association of CAVI and baPWV values with MetS components in males than in females and indicate greater arterial stiffness in the event of simultaneously elevated blood pressure, fasting plasma glucose, and waist circumference
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.relation.isformatof
Reproducció digital del document publicat a: http://dx.doi.org/10.1186/s12933-016-0465-7
dc.relation.ispartof
Cardiovascular Diabetology, 2016, vol. 15, p. 148
dc.relation.ispartofseries
Articles publicats (D-CM)
dc.rights
Attribution 4.0 Spain
dc.rights.uri
dc.subject
dc.title
Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross‑sectional trial
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.embargo.terms
Cap
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.eissn
1475-2840