PFA toolbox: a MATLAB tool for Metabolic Flux Analysis
dc.contributor.author
dc.date.accessioned
2017-05-09T14:47:52Z
dc.date.available
2017-05-09T14:47:52Z
dc.date.issued
2016-07-11
dc.identifier.uri
dc.description.abstract
Metabolic Flux Analysis (MFA) is a methodology that has been successfully applied to estimate metabolic fluxes in living cells. However, traditional frameworks based on this approach have some limitations, particularly when measurements are scarce and imprecise. This is very common in industrial environments. The PFA Toolbox can be used to face those scenarios.
Results
Here we present the PFA (Possibilistic Flux Analysis) Toolbox for MATLAB, which simplifies the use of Interval and Possibilistic Metabolic Flux Analysis. The main features of the PFA Toolbox are the following: (a) It provides reliable MFA estimations in scenarios where only a few fluxes can be measured or those available are imprecise. (b) It provides tools to easily plot the results as interval estimates or flux distributions. (c) It is composed of simple functions that MATLAB users can apply in flexible ways. (d) It includes a Graphical User Interface (GUI), which provides a visual representation of the measurements and their uncertainty. (e) It can use stoichiometric models in COBRA format. In addition, the PFA Toolbox includes a User’s Guide with a thorough description of its functions and several examples.
Conclusions
The PFA Toolbox for MATLAB is a freely available Toolbox that is able to perform Interval and Possibilistic MFA estimations
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.relation.isformatof
Reproducció digital del document publicat a: http://dx.doi.org/10.1186/s12918-016-0284-1
dc.relation.ispartof
BMC Systems Biology, 2016, vol. 10, p. 46
dc.relation.ispartofseries
Articles publicats (D-EEEiA)
dc.rights
Attribution 4.0 Spain
dc.rights.uri
dc.title
PFA toolbox: a MATLAB tool for Metabolic Flux Analysis
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.embargo.terms
Cap
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
031009
dc.identifier.eissn
1752-0509