Determination of pharmaceutical compounds in sewage sludge using a standard addition method approach
dc.contributor.author
dc.date.accessioned
2017-03-02T10:51:27Z
dc.date.available
2017-03-02T10:51:27Z
dc.date.issued
2014-08-12
dc.identifier.issn
0306-7319
dc.identifier.uri
dc.description.abstract
An analytical method for the simultaneous determination of eight pharmaceutical compounds in biosolids from urban wastewater treatment plants (WWTPs) was developed and validated. The compounds evaluated were non-steroidal anti-inflammatory drugs (naproxen, diclofenac, and ibuprofen), lipid regulators (clofibric acid), and antibiotics (sulfathiazole, sulfapyridine, sulfamethazine, and sulfamethoxazole). Ultrasound assisted extraction with a water–methanol solvent mixture (1:1, v:v) was performed and the compounds were then determined by liquid chromatography coupled with tandem mass spectrometry. The design of the method was based on the application of the standard addition calibration methodology to reduce matrix interferences. Validation procedures were conducted with rabbit excrements as blank samples. Recoveries of the target analytes ranged from 76 to 131% in spiked samples at 50, 200 or 1000 ng g−1 dry weight (dw). The relative standard deviations were in the range of 5–15% and the method detection limits ranged from 2 to 12 ng g−1dw. The method was applied to monitor pharmaceutical concentrations in biosolids from different WWTPs over an eight-month period (May to December 2011). Diclofenac, sulfapyridine and ibuprofen were detected in most of the samples whereas sulfamethazine and ibuprofen were the pharmaceuticals found in the highest concentrations (>200 ng g−1 dw on average)
dc.description.sponsorship
The financial support of the Ministerio de Ciencia e Inovación through projects CTM2008-0647-C02-02/TECNO, CTM2011-28765-C02-02 and CGL2010-22168-C03-03 is gratefully acknowledged
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Taylor and Francis
dc.relation
info:eu-repo/grantAgreement/MICINN//CTM2011-28765-C02-02/ES/COMPORTAMIENTO Y ELIMINACION DE CONTAMINANTES ORGANICOS EMERGENTES EN SISTEMAS DE TRATAMIENTOS DE AGUAS. EVALUACION DE SISTEMAS TERCIARIOS./
info:eu-repo/grantAgreement/MICINN//CGL2010-22168-C03-02/ES/APLICACION DE AGUA NO CONVENCIONAL (TRATADA-DESALADA) Y FANGOS PROCEDENTES DE DEPURADORAS URBANAS Y SU IMPACTO EN EL MEDIO ACUIFERO Y SUELOS. ETUDIOS DE CAMPOY LABORATORIO/
dc.relation.isformatof
Reproducció digital del document publicat a: http://dx.doi.org/10.1080/03067319.2014.921292
dc.relation.ispartof
© International Journal of Environmental Analytical Chemistry, 2014, vol. 94, núm. 12, p. 1199-1209
dc.relation.ispartofseries
Articles publicats (D-Q)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Determination of pharmaceutical compounds in sewage sludge using a standard addition method approach
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/embargoedAccess
dc.embargo.terms
Cap
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2026-01-01
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
022353
dc.contributor.funder
dc.relation.ProjectAcronym
dc.identifier.eissn
1029-0397