Determination of 15 N-nitrosodimethylamine precursors in different water matrices by automated on-line solid-phase extraction ultra-high-performance-liquid chromatography tandem mass spectrometry
dc.contributor.author
dc.date.accessioned
2016-11-24T10:44:59Z
dc.date.available
2016-11-24T10:44:59Z
dc.date.issued
2016-08-05
dc.identifier.issn
0021-9673
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dc.description.abstract
A new methodology based on on-line solid-phase extraction (SPE) ultra-high-performance-liquid chromatography coupled to a triple quadrupole mass spectrometer (UHPLC–MS–MS) for the determination of 15 individual anthropogenic N-nitrosodimethylamine (NDMA) precursors was developed. On-line SPE was performed by passing 2 mL of the water sample through a Hypersil GOLD aQ column and chromatographic separation was done using a Kinetex Biphenyl column using methanol and 0.1% formic acid aqueous solution as a mobile phase. For unequivocal identification and confirmation, two selected reaction monitoring (SRM) transitions were monitored per compound. Quantification was performed by internal standard approach and matrix match calibration. The main advantages of the developed method are high sensitivity (limits of detection in the sub ng/L range), selectivity due to the use of tandem mass spectrometry, precision and minimum sample manipulation as well as fast analytical response. Process efficiency and recovery were also evaluated for all the target compounds. As part of the validation procedure, the method was applied in a sampling campaign for the analysis of influent and secondary effluent of a wastewater treatment plant (WWTP) in Girona, Spain. Additionally, the effluent from a nanofiltration (NF) membrane system used for water recycling was monitored. The percentage of NDMA formation explained by the measured precursors was also quantified
dc.description.sponsorship
AcknowledgementsThis study was funded by the Spanish MINECO project Water-Fate (CTM2012-38314-C02-01) and the collaboration between ICRA and Canal de Isabel II Gestión. Dr. Maria José Farré acknowl-edges the European Commission for funding project 623711under the FP7-PEOPLE-2013-IIF—Marie Curie Action: “Interna-tional Incoming Fellowships”. Mr. Julian Mamo acknowledges thefunding received from the People Program (Marie Curie Actions)of the European Union’s Seventh Framework Program FP7/2007-2013, under REQ agreement 289193
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation
info:eu-repo/grantAgreement/MINECO//CTM2012-38314-C02-01/ES/DESTINO DE MICROCONTAMINANTES Y PRODUCTOS DE DESINFECCION EN BIORREACTORES DE MEMBRANAS Y OSMOSIS INVERSA O NANOFILTRACION SEGUIDO DE DESINFECCION./
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Reproducció digital del document publicat a: http://dx.doi.org/10.1016/j.chroma.2016.06.064
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© Journal of Chromatography A, 2016, vol. 1458, p. 99-111
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Articles publicats (ICRA)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Determination of 15 N-nitrosodimethylamine precursors in different water matrices by automated on-line solid-phase extraction ultra-high-performance-liquid chromatography tandem mass spectrometry
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/embargoedAccess
dc.embargo.terms
Cap
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2026-01-01
dc.relation.projectID
info:eu-repo/grantAgreement/EC/FP7/289193/EU/Sustainable and integrated urban water system management/SANITAS
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
025352
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dc.relation.FundingProgramme
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