Peptide-mediated vectorization of metal complexes: conjugation strategies and biomedical applications
dc.contributor.author
dc.date.accessioned
2016-04-06T12:04:52Z
dc.date.available
2017-04-01T03:00:05Z
dc.date.issued
2016-04-01
dc.identifier.issn
1477-9226
dc.identifier.uri
dc.description.abstract
The rich chemical and structural versatility of transition metal complexes provide numerous novel paths to be pursued in the design of molecules that exert particular chemical of physicochemical effects that could operate over specific biological targets. However, the poor cell permeability of metallodrugs represents an important barrier for their therapeutic use. The conjugation between metal complexes and a functional peptide vector can be regarded as a versatile and potential strategy to improve their bioavailability and accumulation inside cells, and the site selectivity of their effect. This perspective lies on reviewing the recent advances on the design of metallopeptide conjugates for biomedical applications. Additionally, we highlight the studies where this approach has been directed towards the incorporation of redox active metal centers in living organisms for modulating the cellular redox balance, as a tool with application in anticancer therapy
dc.description.sponsorship
We acknowledge financial support by Consolider Ingenio CSD/CSD2010-00065 from MICINN of Spain. We also thank the Catalan DIUE of the Generalitat de Catalunya (2014 SGR 862). X.R. thanks financial support from INNPLANTA project INP-2011-0059-PCT-420000-ACT1
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry (RSC)
dc.relation
MICINN/PN 2010-2016/CSD2010-00065
MICINN/PN 2011/INP-2011-0059-PCT-420000
AGAUR/2014-2016/2014 SGR-862
dc.relation.isformatof
Versió postprint del document publicat a: http://dx.doi.org/10.1039/C5DT04529K
dc.relation.ispartof
© Dalton Transactions, 2016, vol 45, núm. 33, p. 12970-12982
dc.relation.ispartofseries
Articles publicats (D-Q)
dc.rights
Tots els drets reservats
dc.source
Soler Vives, Marta Feliu Soley, Lídia Planas i Grabuleda, Marta Ribas Salamaña, Xavi Costas Salgueiro, Miquel 2016 Peptide-mediated vectorization of metal complexes: conjugation strategies and biomedical applications Dalton Transactions
dc.title
Peptide-mediated vectorization of metal complexes: conjugation strategies and biomedical applications
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.identifier.idgrec
024917
dc.contributor.funder
dc.identifier.eissn
1477-9234