An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies

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Gandioso, Albert
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Shaili, Evyenia
orcId Massaguer i Vall-llovera, Anna​ researcherId Massaguer i Vall-llovera, Anna​ scopusId Massaguer i Vall-llovera, Anna​ ​
Massaguer i Vall-llovera, Anna
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Artigas, Gerard
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González-Cantó, Alejandro
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Woods, Julie A.
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Sadler, Evyenia
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Marchán, Vicente
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A new anticancer agent based on the conjugation of a photoactivatable Pt(iv) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing α<inf>V</inf>β<inf>3</inf> integrin compared to control DU-145 human prostate carcinoma cells ​
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