Simple and Sustainable Copper-O 2 Chemistry towards High-Value Products

Abstract

Oxygen meets its end, or does it? Straightforward Cu-catalyzed preparation of α-ketoamides has been recently achieved through oxidative coupling of aryl acetaldehydes and arylamines by using O2 as the terminal oxidant. The work represents a remarkable example of a simple and sustainable transformation to yield elaborate and more complex biologically relevant oxidized products from readily available reagents under mild conditions