In recent years it has detected the presence of pharmaceuticals and endocrine disruptors in aquatic environments. These compounds may accumulate in marine organisms such as fish and shellfish if longZterm exposure and consumption of these organisms occurs could cause a risk to human health. With the main objective to assess this risk arises the European project "Priority environmental contaminants in seafood: safety assessment, impact and public perception" (ECsafeSEAFOOD) within which development has this work. It has analyzed samples of fish and shellfish for human consumption, mainly from different European regions, but have also included some samples of imported organisms. The compounds under study were diruptores endocrine compounds (EDCs) particularly triclosan, methylparaben, bisphenol A and TBEP and pharmacologically active compounds (PHACS) such as diazepam, sotalol, azithromycin, carbamazepine, diclofenac, citalopram, venlafaxine and sulfamethoxazole. Two samplings were conducted at different times of year and also the second one of the samples were steamed. The analysis of samples was performed using two analytical methods multiresidue. The protocol followed for EDCs is based on the use of QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe [fast, easy, economical, efficient, robust and secure]). for extraction and purification sample, while for PHACS pressurized extraction with solvents (PLE) followed by a purification step with gel chromatography (GPC) was use. In both cases the detection and quantification of samples end was performed by chromatography coupled to mass spectrometry (UHPLCZMS) liquid. The results show concentrations of triclosan reaching 183.8 ng/g d.w in North Sea mackerel, and 36.4 ng/g d.w of bisphenol A in canned mackerel from Portugal. Furthermore, there has been an increasing concentration of EDCs when samples were steamed until reaching 75.4 ng/g d.w of bisphenol A in gold. Regarding levels PHACS the highest value was 11.72 ng/g d.w sulfamethoxazole of mussels from Holland. Although the levels detected in some cases are considerable not exceed the maximum levels permitted by the EU. To EDCs measured levels would not present any risk to public health in
accordance with the tolerable daily maximum values recommended by the World Health Organization (WHO)
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