Surgery alone vs surgery plus PRP in the treatment of Medication-related Osteonecrosis of the Jaws: A clinical trial

Abstract

PURPOSE: To compare the incidence of dehiscence after a surgical approach plus PRP versus a surgical approach alone on those patients who suffered from MRONJ and who have clinical signs and symptoms with or without bone exposure. As secondary objectives we define to compare the number of reinterventions performed, the pain symptomatology and the quality of life before and after the treatment in patients treated with a surgical approach plus PRP versus patients treated with a surgical approach alone for the treatment of MRONJ in stage 0, II or III DESIGN: A three years long clinical trial, with simple-blind and randomize distribution of the sample, surgery alone or surgery plus PRP in the treatment of MRONJ