Non conventional biological treatment based on Trametes versicolor for the elimination of recalcitrant anticancer drugs in hospital wastewater
dc.contributor.author
dc.date.accessioned
2015-04-07T15:32:34Z
dc.date.available
2017-04-07T03:00:05Z
dc.date.issued
2015
dc.identifier.issn
0045-6535
dc.identifier.uri
dc.description.abstract
This work presents a study about the elimination of anticancer drugs, a group of pollutants considered recalcitrant during conventional activated sludge wastewater treatment, using a biological treatment based on the fungus Trametes versicolor. A 10-L fluidized bed bioreactor inoculated with this fungus was set up in order to evaluate the removal of 10 selected anticancer drugs in real hospital wastewater. Almost all the tested anticancer drugs were completely removed from the wastewater at the end of the batch experiment (8 d) with the exception of Ifosfamide and Tamoxifen. These two recalcitrant compounds, together with Cyclophosphamide, were selected for further studies to test their degradability by T. versicolor under optimal growth conditions. Cyclophosphamide and Ifosfamide were inalterable during batch experiments both at high and low concentration, whereas Tamoxifen exhibited a decrease in its concentration along the treatment. Two positional isomers of a hydroxylated form of Tamoxifen were identified during this experiment using a high resolution mass spectrometry based on ultra-high performance chromatography coupled to an Orbitrap detector (LTQ-Velos Orbitrap). Finally the identified transformation products of Tamoxifen were monitored in the bioreactor run with real hospital wastewater
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation.isformatof
Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.chemosphere.2015.03.051
dc.relation.ispartof
© Chemosphere, 2015, vol. 136, p. 9-19
dc.relation.ispartofseries
Articles publicats (ICRA)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Non conventional biological treatment based on Trametes versicolor for the elimination of recalcitrant anticancer drugs in hospital wastewater
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.embargo.terms
24 mesos
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2017-06-01
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi