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Josep Puig, Gerard Blasco, Pepus Daunis-i-Estadella, Cecile van Eendendburg, María Carrillo-García, Carlos Aboud, María Hernández-Pérez, Joaquín Serena, Carles Biarnés, Kambiz Nael, David S. Liebeskind, Götz Thomalla, Bijoy K. Menon, Andrew Demchuk, Max Wintermark, Salvador Pedraza, Mar Castellanos
High-permeability region size on perfusion CT predicts hemorrhagic transformation after intravenous thrombolysis in stroke
www.plosone.org
www.plosone.org
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(20)Tj
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(].)Tj
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1 j
1 J
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11.9999 0 0 11.9999 200.0125 477.0141 cm
BT
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3.8154 0 Td
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2.7213 0 Td
(120kVp,)Tj
3.5829 0 Td
(370mAs,)Tj
3.7361 0 Td
(3-mm)Tj
2.6872 0 Td
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1.9389 0 Td
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1.8595 0 Td
(and)Tj
1.7291 0 Td
(512x512)Tj
-32.3997 -1.2983 Td
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2.279 0 Td
(cine)Tj
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2.7212 0 Td
(100kVp,)Tj
3.583 0 Td
(100mAs,)Tj
3.736 0 Td
(and)Tj
1.7291 0 Td
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(10-mm)Tj
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1.4683 0 Td
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3.3051 0 Td
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2.7043 0 Td
(acquisition)Tj
4.6261 0 Td
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2.6022 0 Td
(7)Tj
0.6916 0 Td
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3.3732 0 Td
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3.7587 0 Td
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-34.5824 -1.3039 Td
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4.0195 0 Td
(contrast)Tj
3.464 0 Td
(agent)Tj
2.3867 0 Td
(\(Ultravist)Tj
4.0309 0 Td
(300mgI/mL;)Tj
5.1817 0 Td
(Bayer)Tj
2.4831 0 Td
(HealthCare)Tj
4.8075 0 Td
(Pharmaceutical)Tj
6.412 0 Td
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-33.8001 -1.2982 Td
(Leverkusen,)Tj
5.0116 0 Td
(Germany\))Tj
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1.8425 0 Td
(an)Tj
1.2019 0 Td
(antecubital)Tj
4.6318 0 Td
(vein)Tj
1.9105 0 Td
(at)Tj
0.9525 0 Td
(5)Tj
0.6973 0 Td
(mL/second)Tj
4.6998 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6519 0 Td
(power)Tj
2.7269 0 Td
(injector.)Tj
3.5377 0 Td
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-34.1856 -1.2983 Td
(acquired)Tj
3.702 0 Td
(first-pass)Tj
3.8267 0 Td
(\(25)Tj
1.5137 0 Td
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2.5739 0 Td
(cycle)Tj
2.1883 0 Td
(time)Tj
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(2)Tj
0.6973 0 Td
(seconds\))Tj
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(and)Tj
1.7291 0 Td
(delayed-phase)Tj
5.8677 0 Td
(\(six)Tj
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(contiguous)Tj
4.6544 0 Td
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-34.1515 -1.3039 Td
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2.1883 0 Td
(time)Tj
2.0296 0 Td
(30)Tj
1.1735 0 Td
(seconds\))Tj
3.7134 0 Td
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3.2144 0 Td
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(3)Tj
0.6916 0 Td
(time)Tj
2.0296 0 Td
(frames)Tj
2.9197 0 Td
(with)Tj
1.9955 0 Td
(an)Tj
1.2019 0 Td
(interval)Tj
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(of)Tj
1.0148 0 Td
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(seconds)Tj
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-34.2082 -1.2983 Td
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2.3697 0 Td
(arrival.)Tj
3.0217 0 Td
(c\))Tj
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1.6271 0 Td
(CTA)Tj
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(arch)Tj
1.9785 0 Td
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1.0262 0 Td
(cranial)Tj
2.9423 0 Td
(vertex\):)Tj
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(helical)Tj
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(scanning)Tj
3.8211 0 Td
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2.7213 0 Td
(120kVp,)Tj
-33.7434 -1.2983 Td
(250mAs,)Tj
3.736 0 Td
(0.9-mm)Tj
3.3845 0 Td
(slice)Tj
1.9446 0 Td
(thickness,)Tj
4.1499 0 Td
(0.45-mm)Tj
3.8607 0 Td
(gap,)Tj
1.8652 0 Td
(and)Tj
1.7292 0 Td
(512x512)Tj
3.5376 0 Td
(matrix.)Tj
3.1011 0 Td
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1.61 0 Td
(acquired)Tj
3.702 0 Td
(CTA)Tj
2.177 0 Td
(images)Tj
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(after)Tj
2.0352 0 Td
(an)Tj
1.2019 0 Td
(80-mL)Tj
2.88 0 Td
(bolus)Tj
2.3697 0 Td
(of)Tj
1.0148 0 Td
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3.685 0 Td
(\(300mgI/mL\))Tj
5.6409 0 Td
(injected)Tj
3.3903 0 Td
(at)Tj
0.9524 0 Td
(5)Tj
0.6916 0 Td
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4.6999 0 Td
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1.1792 0 Td
(20)Tj
1.1735 0 Td
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2.5001 0 Td
(solution.)Tj
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-1.3039 -1.2983 Td
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2.8176 0 Td
(postprocessing.)Tj
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7.2566 0 Td
(CBV,)Tj
2.3868 0 Td
(cerebral)Tj
3.4185 0 Td
(blood)Tj
2.5172 0 Td
(flow)Tj
1.9446 0 Td
(\(CBF\),)Tj
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(MTT,)Tj
2.5569 0 Td
(and)Tj
1.7291 0 Td
(time)Tj
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1.0261 0 Td
(peak)Tj
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(\(TTP\))Tj
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2.1203 0 Td
(automatically)Tj
5.6125 0 Td
(calculated)Tj
4.2009 0 Td
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2.211 0 Td
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2.0523 0 Td
(data)Tj
1.9106 0 Td
(using)Tj
2.3924 0 Td
(commercial)Tj
4.9549 0 Td
(software)Tj
3.5886 0 Td
(\(Extended)Tj
4.3427 0 Td
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-33.3862 -1.3039 Td
(workstation)Tj
4.9946 0 Td
(4.5,)Tj
1.6214 0 Td
(Philips)Tj
2.965 0 Td
(Healthcare\).)Tj
5.1307 0 Td
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(manually)Tj
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(placed)Tj
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(anterior)Tj
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(cerebral)Tj
3.4186 0 Td
(artery.)Tj
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1.7801 0 Td
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(the)Tj
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(enhancement)Tj
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(the)Tj
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3.0671 0 Td
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(and)Tj
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(the)Tj
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(sagittal)Tj
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(sinus)Tj
2.2847 0 Td
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(the)Tj
1.4683 0 Td
(venous)Tj
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(output)Tj
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(function.)Tj
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(core)Tj
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(by)Tj
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(default)Tj
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(defined)Tj
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0 Tc
2.1599 0 Td
(<)Tj
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-0.004 Tc
0.9865 0 Td
(2)Tj
0.6973 0 Td
(ml/100g,)Tj
3.7361 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(penumbra)Tj
4.371 0 Td
(as)Tj
1.0148 0 Td
(MTT)Tj
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0 Tc
2.3357 0 Td
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-0.004 Tc
0.9865 0 Td
(145%)Tj
2.4038 0 Td
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0 Tc
2.1543 0 Td
()Tj
/F6 1 Tf
-0.004 Tc
0.9921 0 Td
(2)Tj
0.6973 0 Td
(ml/100g.)Tj
3.7304 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(])Tj
1.3776 0 Td
(BBB)Tj
1.9616 0 Td
(permeability)Tj
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(calculated)Tj
4.2066 0 Td
(with)Tj
1.9956 0 Td
(commercial)Tj
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(based)Tj
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(on)Tj
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1.4626 0 Td
(Patlak)Tj
2.6872 0 Td
(model)Tj
2.7383 0 Td
(\(Intellispace)Tj
5.0853 0 Td
(Portal)Tj
2.6362 0 Td
(system,)Tj
3.1578 0 Td
(Philips)Tj
2.9593 0 Td
(Healthcare\).)Tj
5.1364 0 Td
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1.7745 0 Td
(Patlak)Tj
2.6872 0 Td
(model)Tj
2.7382 0 Td
(uses)Tj
1.8879 0 Td
(linear-)Tj
-34.9509 -1.3039 Td
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1.8425 0 Td
(regression)Tj
4.3143 0 Td
(for)Tj
1.3776 0 Td
(estimating)Tj
4.3993 0 Td
(the)Tj
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1.4627 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 340.3842 191.4519 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(trans)Tj
ET
Q
q
1 j
1 J
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BT
/F6 1 Tf
1 TL
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1.4683 0 Td
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(volume,)Tj
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(fitting)Tj
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(regression)Tj
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1.0261 0 Td
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(of)Tj
1.0148 0 Td
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(curves)Tj
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(each)Tj
2.0296 0 Td
(pixel)Tj
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(and)Tj
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(for)Tj
1.389 0 Td
(intravascular)Tj
5.3914 0 Td
(reference)Tj
3.9175 0 Td
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-35.3874 -1.2983 Td
(tion.)Tj
2.0636 0 Td
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1.7858 0 Td
(slopes)Tj
2.6362 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2507 0 Td
(lines)Tj
2.0693 0 Td
(represent)Tj
3.957 0 Td
(local)Tj
2.075 0 Td
(blood-to-brain)Tj
6.1511 0 Td
(transfer)Tj
3.3165 0 Td
(constants)Tj
3.9969 0 Td
(that)Tj
1.7801 0 Td
(indicate)Tj
-33.097 -1.2982 Td
(BBB)Tj
1.9559 0 Td
(permeability)Tj
5.2497 0 Td
(\()Tj
/F10 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 281.9338 152.4472 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(trans)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 299.1685 148.0251 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(in)Tj
1.0374 0 Td
(mL/100g/min\).)Tj
6.3269 0 Td
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0.8617 0 Td
(is)Tj
0.8448 0 Td
(important)Tj
4.2802 0 Td
(to)Tj
1.0262 0 Td
(mention)Tj
3.634 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4684 0 Td
(leakage)Tj
3.1407 0 Td
(is)Tj
0.8504 0 Td
(irre-)Tj
-35.1663 -1.3039 Td
(versible,)Tj
3.498 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(attenuation)Tj
4.8017 0 Td
(curves)Tj
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(are)Tj
1.4457 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(near)Tj
2.0013 0 Td
(steady-state.)Tj
5.108 0 Td
(We)Tj
1.6101 0 Td
(applied)Tj
3.1521 0 Td
(different)Tj
3.6566 0 Td
(thresholds)Tj
-32.9496 -1.2982 Td
(on)Tj
/F10 1 Tf
1.2756 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 219.1748 126.4251 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(trans)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 236.4094 122.0031 cm
BT
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