Multi-residue method for the determination of antibiotics and some of their metabolites in seafood

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dc.contributor.author Serra Compte, Albert
dc.contributor.author Álvarez-Muñoz, Diana
dc.contributor.author Rodríguez Mozaz, Sara
dc.contributor.author Barceló i Cullerés, Damià
dc.date.issued 2017-06-01
dc.identifier.issn 0278-6915
dc.identifier.uri http://hdl.handle.net/10256/14366
dc.description El títol de la versió postprint d'aquest article és: 'Fast methodology for the determination of a broad set of antibiotics and some of their metabolites in seafood'
dc.description.abstract The presence of antibiotics in seafood for human consumption may pose a risk for consumers. A methodology for the analysis of antibiotics in seafood based on QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction, followed by detection and quantification using liquid chromatography coupled to mass spectrometry was developed. The analytical method was evaluated for the determination of 23 antibiotics (including parent compounds and some metabolites) in fish, mussels and clams. Recoveries ranged between 30% and 70% for most of the compounds and method detection and quantification limits (MDLs and MQLs) were between 0.01 and 0.31 ng/g dry weigh (dw) and 0.02–1.03 ng/g (dw) respectively. Real seafood samples were analysed using this method. Nine antibiotics were found at levels above MDLs; however none of them exceed the maximum residue limits (MRL) established by the authorities. Tetracycline was the most ubiquitous compound, presenting also the highest concentration: 5.63 ng/g (dw) in fish from Netherlands. In addition, an alternative technique based on microbial growth inhibition was explored as semiquantitative detection method of antibiotics in seafood. This methodology c ould be applied as a fast screening technique for the detection of macrolides and β-lactams in seafood but further research is needed for other antibiotics families
dc.description.sponsorship The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under the ECsafeSEAFOOD project (grant agreement n° 311820) and the SEA-on-a-CHIP project (grant agreement no. 614168). It has been co-financed by the European Union through the European Regional Development Fund (ERDF). This work has also been partly funded by the Generalitat de Catalunya (Consolidated Research Groups 2014-SGR-291-Catalan Institute for Water Research 2014 & 2014-SGR-418-Water and Soil Quality Unit)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.isformatof Versió postprint del document publicat a: https://doi.org/10.1016/j.fct.2016.11.031
dc.relation.ispartof © Food and Chemical Toxicology, 2017, vol. 104, p. 3-13
dc.relation.ispartofseries Articles publicats (ICRA)
dc.rights Tots els drets reservats
dc.subject Antibiòtics
dc.subject Antibiotics
dc.subject Cromatografia de líquids
dc.subject Liquid chromatography
dc.subject Espectrometria de masses
dc.subject Mass spectrometry
dc.subject Contaminants emergents en l'aigua
dc.subject Emerging contaminants in water
dc.subject Toxicologia ambiental
dc.subject Environmental toxicology
dc.subject Marisc -- Toxicologia
dc.subject Seafood -- Toxicology
dc.title Multi-residue method for the determination of antibiotics and some of their metabolites in seafood
dc.type info:eu-repo/semantics/article
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.embargo.lift 2018-09-07T07:24:24Z
dc.embargo.terms 12 mesos
dc.date.embargoEndDate info:eu-repo/date/embargoEnd/2018-06-01
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/311820
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/614168
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.identifier.doi https://doi.org/10.1016/j.fct.2016.11.031


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