Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study
dc.contributor.author
dc.date.accessioned
2017-06-22T11:22:44Z
dc.date.available
2017-06-22T11:22:44Z
dc.date.issued
2017-05-09
dc.identifier.issn
2045-2322
dc.identifier.uri
dc.description.abstract
The capacity to respond to novel events is crucial for adapting to the constantly changing environment.
Here, we recorded 29-channel Event Related Brain Potentials (ERPs) during an active auditory novelty
oddball paradigm and used for the first time Current Source Density-transformed Event Related Brain
Potentials and associated time-frequency spectra to study target and novelty processing in a group of
epileptic patients with unilateral damage of the hippocampus (N = 18) and in healthy matched control
participants (N = 18). Importantly, we used Voxel-Based Morphometry to ensure that our group of
patients had a focal unilateral damage restricted to the hippocampus and especially its medial part.
We found a clear deficit for target processing at the behavioral level. In addition, compared to controls,
our group of patients presented (i) a reduction of theta event-related synchronization (ERS) for targets
and (ii) a reduction and delayed P3a source accompanied by reduced theta and low-beta ERS and alpha
event-related synchronization (ERD) for novel stimuli. These results suggest that the integrity of the
hippocampus might be crucial for the functioning of the complex cortico-subcortical network involved
in the detection of novel and target stimuli
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.relation.isformatof
Reproducció digital del document publicat a: http://dx.doi.org/10.1038/s41598-017-01531-8
dc.relation.ispartof
Scientific Reports, 2017, vol.7, art. núm. 1612
dc.relation.ispartofseries
Articles publicats (D-PS)
dc.rights
Attribution 3.0 Spain
dc.rights.uri
dc.subject
dc.title
Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.embargo.terms
Cap
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi