DUGiDocsUV/H2O2 degradation of the antidepressants venlafaxine and O-desmethyl venlafaxine: Elucidation of their transformation pathwayand environmental fate
dc.contributor.author
dc.date.accessioned
2016-11-30T07:12:43Z
dc.date.available
2016-11-30T07:12:43Z
dc.date.issued
2016-07-05
dc.identifier.issn
0304-3894
dc.identifier.uri
dc.description.abstract
The aim of the present work is to investigate the removal and transformation of the antidepressants venlafaxine (VFX) and its main metabolite O-desmethylvenlafaxine (DVFX) upon advanced oxidation with UV/H2O2 under lab conditions. High-resolution mass spectrometry (HRMS) analyses were carried out by means of ultra-high pressure liquid chromatography (UHPLC)-linear ion trap high resolution Orbitrap instrument (LTQ-Orbitrap-MS) in order to elucidate the different transformation products (TPs) generated. The depletion of both VFX and DVFX was very significant, with the 99.9% of both compounds eliminated after 5 and 30 min of reaction, respectively. Eleven TPs for VFX and six for DVFX were detected and their molecular structures elucidated by means of MS2 and MS3 scans, and the corresponding degradation pathways were proposed. The combined ecotoxicity at different treatment times was evaluated by means of bioluminescence inhibition assays with the marine bacteria Vibrio fischeri. Results showed an increase in the ecotoxicity during the UV/H2O2 experiment, especially at those reaction times where the total abundance of TPs was higher
dc.description.sponsorship
AcknowledgementsThe authors would like to thank the European Union (MarieCurie SANITAS ITN Project agreement 289193) and the SpanishMinistry of Science and Innovation (PCIN-2013-074, CTM2012-38314-C02-01 and CTM2013- 48545-C2). This research has alsobeen co-financed by the European Union through the EuropeanRegional Development Fund (ERDF) in the frame of the Catalo-nia ERDF Operative programme 2007–2013. This work was partlysupported by the Generalitat de Catalunya (Consolidated ResearchGroup: Catalan Institute for water Research 2014 SGR 291). R.Gonzalez-Olmos thanks to “Obra Social La Caixa” for fundingthrough the “Electromembrane” (2014-URL-Trac-002)
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation
info:eu-repo/grantAgreement/MINECO//PCIN-2013-074/ES/MODELADO, CONTROL Y SISTEMAS DE AYUDA A LA DECISION AVANZADOS PARA EL DISEÑO Y OPERACION DE SISTEMAS DE SANEAMIENTO DE AGUAS RESIDUALES FLEXIBLES Y OPTIMOS./
info:eu-repo/grantAgreement/MINECO//CTM2012-38314-C02-01/ES/DESTINO DE MICROCONTAMINANTES Y PRODUCTOS DE DESINFECCION EN BIORREACTORES DE MEMBRANAS Y OSMOSIS INVERSA O NANOFILTRACION SEGUIDO DE DESINFECCION./
MINECO/PN 2013-2016/CTM2013-48545-C2-2-R
dc.relation.isformatof
Reproducció digital del document publicat a: http://dx.doi.org/10.1016/j.jhazmat.2016.02.070
dc.relation.ispartof
© Journal of Hazardous Materials, 2016, vol. 311, p. 70-80
dc.relation.ispartofseries
Articles publicats (D-EQATA)
dc.rights
Tots els drets reservats
dc.subject
dc.title
UV/H2O2 degradation of the antidepressants venlafaxine and O-desmethyl venlafaxine: Elucidation of their transformation pathwayand environmental fate
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/embargoedAccess
dc.embargo.terms
Cap
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2026-01-01
dc.relation.projectID
info:eu-repo/grantAgreement/EC/FP7/289193/EU/Sustainable and integrated urban water system management/SANITAS
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
024870
dc.contributor.funder
dc.relation.FundingProgramme
dc.relation.ProjectAcronym
dc.identifier.eissn
1873-3336