Nonconvulsive status epilepticus: association between EEG patterns and alterations and outcome

Abstract

BACKGROUND

Status epilepticus (SE) is a common neurological emergence with a high mortality and high range of sequelae in survivor patients. It is classified as convulsive (CSE) and non-convulsive (NCSE) status epilepticus. Both require prompt diagnosis and management, nevertheless there is a lack of information regarding NCSE prognosis and therapeutic decisions. For that reason, nowadays, the main investigations in this field are related to outcome and management of NCSE, mainly with the first one as to know the possible good or bad outcome of the patient, the management and related decisions would be easier. As the electroencephalogram (EEG) is the main tool in NCSE diagnosis and is a mandatory test in these patients, a growing body of the literature suggests that there is a relationship between EEG alterations or patterns and the NCSE outcome although this association has not been clarified yet.

AIMS

Our main aim is to identify the relationship between the EEG patterns and alterations and the prognosis in NCSE. Our secondary aims are to determine if the EEG patterns or alterations give information for refractory status epilepticus (RSE) prediction in NCSE and to determinate if the association between EEG patterns and prognosis or evolution in NCSE is the same in paediatric, adult and elderly population.

METHODS

We suggest a retrospective multicentre cohort using a sample of approximately 1492 patients with clinical and electroencephalographic NCSE diagnosis