Speciation of arsenic in saliva samples from a population of West Bengal, India
dc.contributor.author
dc.date.accessioned
2016-01-25T13:16:33Z
dc.date.available
2016-01-25T13:16:33Z
dc.date.issued
2014
dc.identifier.issn
0013-936X
dc.identifier.uri
dc.description.abstract
Saliva, an easily accessible biofluid, is validated as biomarker of arsenic (As) exposure in several villages of West Bengal, India. Pentavalent arsenic [As(V)] was found to be the predominant species in saliva, with the amount of inorganic As [As(V) and trivalent form, As(III)] being more than half of the total As in the samples. Significant association was found between total daily ingestion of As and As(V) (r = 0.59; p = 0.000), As(III) (r = 0.60; p = 0.000), dimethylarsinous acid (DMAV) (r = 0.40; p = 0.000), and monomethylarsonous acid (MMAV) (r = 0.44; p = 0.000), implying that these species have mainly been derived from the methylation of the inorganic As in the water that study participants drank and the food they ate. Analysis of confounding effects of age, sex, smoking, body mass index and the prevalence of skin lesion suggests that women and controls with no skin lesion had a higher capacity to methylate the ingested As compared to the rest of the population. Thus, our study demonstrates that As species in saliva can be an useful tool to predict the individual susceptibility where higher As exposure and a lower methylation capacity are implicated in the development of As-induced health effects
dc.description.sponsorship
We also acknowledge the support from the Spanish National Research Programme (CGL2010-22168-C03-03). S.B. and D.H. acknowledge Erasmus Mundus External Cooperation Window (EMECW Action II) Program EUR-INDIA
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society (ACS)
dc.relation
info:eu-repo/grantAgreement/MICINN//CGL2010-22168-C03-02/ES/APLICACION DE AGUA NO CONVENCIONAL (TRATADA-DESALADA) Y FANGOS PROCEDENTES DE DEPURADORAS URBANAS Y SU IMPACTO EN EL MEDIO ACUIFERO Y SUELOS. ETUDIOS DE CAMPOY LABORATORIO/
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Reproducció digital del document publicat a: http://dx.doi.org/10.1021/es4056142
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© Environmental Science and Technology, 2014, vol. 48, núm. 12, p. 6973-6980
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Articles publicats (D-Q)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Speciation of arsenic in saliva samples from a population of West Bengal, India
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/embargoedAccess
dc.embargo.terms
Cap
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2026-01-01
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
023355
dc.contributor.funder
dc.relation.ProjectAcronym
dc.identifier.eissn
1520-5851