Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel
dc.contributor.author
dc.date.accessioned
2015-05-11T10:36:41Z
dc.date.available
2015-05-11T10:36:41Z
dc.date.issued
2015
dc.identifier.issn
0939-4451
dc.identifier.uri
dc.description.abstract
Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Nav1.5. We show that Nav1.5 R513 methylation decreases S516 phosphorylation rate by 4 orders of magnitude, the first evidence of protein kinase A inhibition by arginine methylation. Reciprocally, S516 phosphorylation blocks R513 methylation. Nav1.5 p.G514C, associated to cardiac conduction disease, abrogates R513 methylation, while leaving S516 phosphorylation rate unchanged. This is the first report of methylation-phosphorylation cross-talk of a cardiac ion channel
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Springer Verlag
dc.relation
info:eu-repo/grantAgreement/MICINN//CTQ2011-25086/ES/MODELIZACION MULTIESCALAR EN (BIO)QUIMICA/
info:eu-repo/grantAgreement/MICINN//SAF2011-27627/ES/ESTUDIO DE LOS MECANISMOS MOLECULARES QUE REGULAN LA EXPRESION Y FUNCION DE SCN5A/
dc.relation.isformatof
Reproducció digital del document publicat a: http://dx.doi.org/10.1007/s00726-014-1890-0
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© Amino Acids, 2015, vol. 47, núm. 2, p. 429-434
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Articles publicats (D-Q)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/embargoedAccess
dc.embargo.terms
Cap
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2026-01-01
dc.relation.projectID
info:eu-repo/grantAgreement/EC/FP7/630978/EU/Computational Exploration of Directed Evolution rules for tuning enzymatic activities/DIREVENZYME
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
023106
dc.contributor.funder
dc.relation.FundingProgramme
dc.relation.ProjectAcronym
dc.identifier.eissn
1438-2199