Publicacions de projectes del 7è Programa Marc de la UEhttp://hdl.handle.net/10256/80102024-03-28T16:16:15Z2024-03-28T16:16:15ZLack of adverse effects in subchronic and chronic toxicity/ carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC ratsSteinberg, PabloVoet, Hilto van derGoedhart, Paul W.Kleter, Gijs A.Kok, Esther J.Pla i de Solà-Morales, MariaNadal i Matamala, AnnaZeljenková, DagmarAláčová, RadkaBabincová, JúliaRollerová, EvaJaďuďová, SoňaKebis, AntonSzabová, ElenaTulinská, JanaLíšková, AuréliaTakácsová, MelindaLehotská Mikušová, MiroslavaKrivošíková, ZoraSpök, ArminRacovita, MonicaVriend, Huib deAlison, RogerAlison, ClareBaumgärtner, WolfgangBecker, KathrinLempp, CharlotteSchmicke, MarionSchrenk, DieterPöting, AnnetteSchiemann, JoachimWilhelm, Ralfhttp://hdl.handle.net/10256/182072021-01-08T08:58:54Z2019-02-12T00:00:00ZLack of adverse effects in subchronic and chronic toxicity/ carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats
Steinberg, Pablo; Voet, Hilto van der; Goedhart, Paul W.; Kleter, Gijs A.; Kok, Esther J.; Pla i de Solà-Morales, Maria; Nadal i Matamala, Anna; Zeljenková, Dagmar; Aláčová, Radka; Babincová, Júlia; Rollerová, Eva; Jaďuďová, Soňa; Kebis, Anton; Szabová, Elena; Tulinská, Jana; Líšková, Aurélia; Takácsová, Melinda; Lehotská Mikušová, Miroslava; Krivošíková, Zora; Spök, Armin; Racovita, Monica; Vriend, Huib de; Alison, Roger; Alison, Clare; Baumgärtner, Wolfgang; Becker, Kathrin; Lempp, Charlotte; Schmicke, Marion; Schrenk, Dieter; Pöting, Annette; Schiemann, Joachim; Wilhelm, Ralf
In 2012, a controversial study on the long-term toxicity of a Roundup herbicide and the glyphosate-tolerant genetically modified (GM) maize NK603 was published. The EC-funded G-TwYST research consortium tested the potential subchronic and
chronic toxicity as well as the carcinogenicity of the glyphosate-resistant genetically modified maize NK603 by performing
two 90-day feeding trials, one with GM maize inclusion rates of 11 and 33% and one with inclusion rates of up to 50%, as
well as a 2-year feeding trial with inclusion rates of 11 and 33% in male and female Wistar Han RCC rats by taking into
account OECD Guidelines for the testing of chemicals and EFSA recommendations on the safety testing of whole-food/feed
in laboratory animals. In all three trials, the NK603 maize, untreated and treated once with Roundup during its cultivation,
and the conventional counterpart were tested. Differences between each test group and the control group were evaluated.
Equivalence was assessed by comparing the observed difference to differences between non-GM reference groups in previous studies. In case of significant differences, whether the effects were dose-related and/or accompanied by changes in
related parameters including histopathological findings was evaluated. It is concluded that no adverse effects related to the
feeding of the NK603 maize cultivated with or without Roundup for up to 2 years were observed. Based on the outcome of
the subchronic and combined chronic toxicity/carcinogenicity studies, recommendations on the scientific justification and
added value of long-term feeding trials in the GM plant risk assessment process are presented
Hi ha una correcció d'aquest article publicat a Archives of Toxicology (2020) 94:1779–1781, disponible a https://doi.org/10.1007/s00204-020-02751-0
2019-02-12T00:00:00ZTowards Autonomous Robotic Valve TurningCarrera Viñas, ArnauAhmadzadeh, S.R.Ajoudani, A.Kormushev, PetarCarreras Pérez, MarcCaldwell, D.G.http://hdl.handle.net/10256/173572020-02-11T12:02:37Z2013-03-22T00:00:00ZTowards Autonomous Robotic Valve Turning
Carrera Viñas, Arnau; Ahmadzadeh, S.R.; Ajoudani, A.; Kormushev, Petar; Carreras Pérez, Marc; Caldwell, D.G.
In this paper an autonomous intervention robotic task to learn the skill of
grasping and turning a valve is described. To resolve this challenge a set of
different techniques are proposed, each one realizing a specific task and sending
information to the others in a Hardware-In-Loop (HIL) simulation. To improve the
estimation of the valve position, an Extended Kalman Filter is designed. Also to
learn the trajectory to follow with the robotic arm, Imitation Learning approach is
used. In addition, to perform safely the task a fuzzy system is developed which
generates appropriate decisions. Although the achievement of this task will be used
in an Autonomous Underwater Vehicle, for the first step this idea has been tested in
a laboratory environment with an available robot and a sensor
2013-03-22T00:00:00ZLearning by demonstration applied to underwater interventionCarrera Viñas, ArnauPalomeras Rovira, NarcísHurtós Vilarnau, NatàliaKormushev, PetarCarreras Pérez, Marchttp://hdl.handle.net/10256/173562021-07-01T10:18:18Z2014-01-01T00:00:00ZLearning by demonstration applied to underwater intervention
Carrera Viñas, Arnau; Palomeras Rovira, Narcís; Hurtós Vilarnau, Natàlia; Kormushev, Petar; Carreras Pérez, Marc
Performing subsea intervention tasks is a challenge due to the complexities of the underwater domain. We propose to use a learning by demonstraition
algorithm to intuitively teach an intervention autonomous underwater vehicle (IAUV) how to perform a given task. Taking as an input few operator demonstrations, the algorithm generalizes the task into a model and simultaneously controls
the vehicle and the manipulator (using 8 degrees of freedom) to reproduce the task.
A complete framework has been implemented in order to integrate the LbD algorithm with the different onboard sensors and actuators. A valve turning intervention
task is used to validate the full framework through real experiments conducted in a
water tank
Comunicació de congrés presentada a: 17th International Conference of the Catalan Association for Artificial Intelligence, Barcelona, Catalonia, Spain, October 22-24, 2014
2014-01-01T00:00:00ZChemo-Divergent Nickel(0)-Catalyzed Arene C-F Activation with Alkynes: Unprecedented C-F/C-H Double-InsertionCapdevila Güell, LorenaMeyer, Tjark H.Roldán Gómez, StevenLuis Luis, Josep MariaAckermann, LutzRibas Salamaña, Xavihttp://hdl.handle.net/10256/172272021-04-07T08:03:01Z2019-10-09T00:00:00ZChemo-Divergent Nickel(0)-Catalyzed Arene C-F Activation with Alkynes: Unprecedented C-F/C-H Double-Insertion
Capdevila Güell, Lorena; Meyer, Tjark H.; Roldán Gómez, Steven; Luis Luis, Josep Maria; Ackermann, Lutz; Ribas Salamaña, Xavi
Nickel-catalyzed C-F activations enabled chemodivergent C-C formation with alkynes by chelation assistance. The judicious choice of the alkyne electronic properties allowed the selective synthesis of double-insertion aromatic homologation or alkyne monoannulation products by C-F/C-H activation. On the basis of the unambiguous crystallographic characterization of an unprecedented nine-membered nickelacyclic intermediate and extensive DFT studies, a plausible mechanistic rationale was established for the selective C-F activation and the chemodivergent catalysis
2019-10-09T00:00:00Z